Culture-independent detection and characterisation of <i>Mycobacterium tuberculosis</i> and <i>M. africanum</i> in sputum samples using shotgun metagenomics on a benchtop sequencer

Abstract excerpt

Tuberculosis remains a major global health problem. Laboratory diagnostic methods that allow effective, early detection of cases are central to management of tuberculosis in the individual patient and in the community. Since the 1880s, laboratory diagnosis of tuberculosis has relied primarily on microscopy and culture. However, microscopy fails to provide species- or lineage-level identification and culture-based...

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