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Article

Loss of TC-PTP in keratinocytes leads to increased UVB-induced autophagy

28 Feb 2025

Abstract excerpt

Ultraviolet B (UVB) radiation can distort cellular homeostasis and predispose the skin to carcinogenesis. Amongst the deteriorating effects of the sun's UVB radiation on cellular homeostasis is the formation of DNA photoproducts. These photoproducts can cause significant changes in the structure and conformation of DNA, inducing gene mutations which may accumulate to trigger the formation of skin cancer....

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PMID: 40021617
DOI: 10.1038/s41420-025-02353-8

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