Article

Personalized and graph genomes reveal missing signal in epigenomic data

2018-10-31

Abstract excerpt

<h4>Background</h4> Epigenomic studies that use next generation sequencing experiments typically rely on the alignment of reads to a reference sequence. However, because of genetic diversity and the diploid nature of the human genome, we hypothesized that using a generic reference could lead to incorrectly mapped reads and bias downstream results. <h4>Results</h4> We show that accounting for genetic variation us...

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Literature Corpus work: 129f291b-1f2d-5754-8769-d1905599beba
DOI: 10.1101/457101

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