Article

Personalized Pangenome References

2023-12-14

Abstract excerpt

Pangenomes, by including genetic diversity, should reduce reference bias by better representing new samples compared to them. Yet when comparing a new sample to a pangenome, variants in the pangenome that are not part of the sample can be misleading, for example, causing false read mappings. These irrelevant variants are generally rarer in terms of allele frequency, and have previously been dealt with using allele...

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Identifiers and source

Literature Corpus work: dc641d73-3d81-51e7-bca1-cef91a85ef41
DOI: 10.1101/2023.12.13.571553

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