Pangenome-based human genome analysis improves trait association and genomic prediction

Abstract excerpt

The Human Pangenome Reference Consortium has generated 462 open-access reference genomes and a variation graph that represents differences among them, providing a substrate for pangenome-based analysis methods that overcome the longstanding limitation of comparing all genomic data to a single linear reference. A key unresolved question is the extent to which these approaches can improve trait mapping. We investiga...

Topics

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• Diabetes Mellitus, Type 2
• Genetics, Population
• Genome, Human
• Genome-Wide Association Study
• Linkage Disequilibrium
• Phenotype
• Polymorphism, Single Nucleotide
• Population Groups

Identifiers and source

Literature Corpus work

3eb0811d-d8d1-5565-a37e-fddf862a0b25

DOI

10.64898/2026.07.01.735728