Article

Pangenome Graph Construction from Genome Alignment with Minigraph-Cactus

2022-10-07

Abstract excerpt

Reference genomes provide mapping targets and coordinate systems but introduce biases when samples under study diverge sufficiently from them. Pangenome references seek to address this by storing a representative set of diverse haplotypes and their alignment, usually as a graph. Alternate alleles determined by variant callers can be used to construct pangenome graphs, but thanks to advances in long-read sequencing...

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Literature Corpus work: 37817114-8ed3-5986-8e39-d755507c80d4
DOI: 10.1101/2022.10.06.511217

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