Article

Estimating differing causal roles of glutamate and GABA genes on brain and behavior in autism

2025-04-16

Abstract excerpt

The excitatory/inhibitory (E/I) imbalance theory suggests that excitatory and inhibitory alterations underlies autism characteristics. However, genetic underpinnings of this imbalance and its impact on brain function and behavior remains unclear. We explored causal links between glutamate and GABA gene-set polygenic scores (PGS) for autism and core autism characteristics, putting particular attention on the restri...

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Literature Corpus work: e179fbdd-4e87-54b3-8f58-824cab236678
DOI: 10.1101/2025.04.11.25325636

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