Article
Targeted sequencing in candidate genes for atrial fibrillation: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Targeted Sequencing Study.
Heart rhythm - 1 Mar 2014
Lin Honghuang, Sinner Moritz F, Brody Jennifer A, Arking Dan E, Lunetta Kathryn L, Rienstra Michiel, Lubitz Steven A, Magnani Jared W, Sotoodehnia Nona, McKnight Barbara, McManus David D, Boerwinkle Eric, Psaty Bruce M, Rotter Jerome I, Bis Joshua C, Gibbs Richard A, Muzny Donna, Kovar Christie L, Morrison Alanna C, Gupta Mayetri, Folsom Aaron R, Kääb Stefan, Heckbert Susan R, Alonso Alvaro, Ellinor Patrick T, Benjamin Emelia J
Abstract excerpt
BACKGROUND: Genome-wide association studies (GWAS) have identified common genetic variants that predispose to atrial fibrillation (AF). It is unclear whether rare and low-frequency variants in genes implicated by such GWAS confer additional risk of AF. OBJECTIVE: To study the association of genetic variants with AF at GWAS top loci. METHODS: In the Cohorts for Heart and Aging Research in Genomic Epidemiology...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.