Article
Whole-exome sequencing in familial atrial fibrillation.
European heart journal - 21 Sept 2014
Weeke Peter, Muhammad Raafia, Delaney Jessica T, Shaffer Christian, Mosley Jonathan D, Blair Marcia, Short Laura, Stubblefield Tanya, Roden Dan M, Darbar Dawood
Abstract excerpt
AIMS: Positional cloning and candidate gene approaches have shown that atrial fibrillation (AF) is a complex disease with familial aggregation. Here, we employed whole-exome sequencing (WES) in AF kindreds to identify variants associated with familial AF. METHODS AND RESULTS: WES was performed on 18 individuals in six modestly sized familial AF kindreds. After filtering very rare variants by multiple metrics, we...
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