Article

Three positively charged binding sites on the eastern equine encephalitis virus E2 glycoprotein coordinate heparan sulfate- and protein receptor-dependent infection

2024-11-04

Abstract excerpt

<h4>SUMMARY</h4> Naturally circulating strains of eastern equine encephalitis virus (EEEV) bind heparan sulfate (HS) receptors and this interaction has been linked to its neurovirulence. Previous studies associated EEEV-HS interactions with three positively charged amino acid clusters on the E2 glycoprotein. One of these sites has recently been reported to be critical for binding EEEV to very-low-density lipoprot...

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Literature Corpus work: 1256e8b0-37a3-5fa6-8271-d745d7f6a21b
DOI: 10.1101/2024.11.04.621500

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