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Article

The VLDLR entry receptor is required for the pathogenesis of multiple encephalitic alphaviruses

1 Oct 2024

Abstract excerpt

The very-low-density lipoprotein receptor (VLDLR) has been reported as an entry receptor for Semliki Forest (SFV) and Eastern equine encephalitis (EEEV) alphaviruses in cell cultures. However, the role of VLDLR in alphavirus pathogenesis and the extent to which other alphaviruses can engage VLDLR remains unclear. Here, using a surface protein-targeted CRISPR-Cas9 screen, we identify VLDLR as a receptor for...

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Identifiers

PMID: 39369384
DOI: 10.1016/j.celrep.2024.114809

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