Article

Novel Scheme for Defining the Clinical Implications of TP53 Mutations in Myeloid Neoplasia

2023-03-09

Abstract excerpt

<h4>Background: </h4> TP53 mutations ( TP53 MT ) occur in diverse genomic configurations. Particularly, biallelic inactivation is associated with poor overall survival in cancer. Lesions affecting only one allele might not be directly leukemogenic, questioning the presence of cryptic biallelic subclones in cases with dismal prognosis. <h4>Methods: </h4>: We have collected clinical and molecular data of 7400 patie...

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Literature Corpus work: 123a8a18-21f8-5cac-ac95-e083f7f394b6
DOI: 10.21203/rs.3.rs-2656206/v1

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