Article
Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes.
Nature medicine - 1 Oct 2020
Bernard Elsa, Nannya Yasuhito, Hasserjian Robert P, Devlin Sean M, Tuechler Heinz, Medina-Martinez Juan S, Yoshizato Tetsuichi, Shiozawa Yusuke, Saiki Ryunosuke, Malcovati Luca, Levine Max F, Arango Juan E, Zhou Yangyu, Solé Francesc, Cargo Catherine A, Haase Detlef, Creignou Maria, Germing Ulrich, Zhang Yanming, Gundem Gunes, Sarian Araxe, van de Loosdrecht Arjan A, Jädersten Martin, Tobiasson Magnus, Kosmider Olivier, Follo Matilde Y, Thol Felicitas, Pinheiro Ronald F, Santini Valeria, Kotsianidis Ioannis, Boultwood Jacqueline, Santos Fabio P S, Schanz Julie, Kasahara Senji, Ishikawa Takayuki, Tsurumi Hisashi, Takaori-Kondo Akifumi, Kiguchi Toru, Polprasert Chantana, Bennett John M, Klimek Virginia M, Savona Michael R, Belickova Monika, Ganster Christina, Palomo Laura, Sanz Guillermo, Ades Lionel, Della Porta Matteo Giovanni, Elias Harold K, Smith Alexandra G, Werner Yesenia, Patel Minal, Viale Agnès, Vanness Katelynd, Neuberg Donna S, Stevenson Kristen E, Menghrajani Kamal, Bolton Kelly L, Fenaux Pierre, Pellagatti Andrea, Platzbecker Uwe, Heuser Michael, Valent Peter, Chiba Shigeru, Miyazaki Yasushi, Finelli Carlo, Voso Maria Teresa, Shih Lee-Yung, Fontenay Michaela, Jansen Joop H, Cervera José, Atsuta Yoshiko, Gattermann Norbert, Ebert Benjamin L, Bejar Rafael, Greenberg Peter L, Cazzola Mario, Hellström-Lindberg Eva, Ogawa Seishi, Papaemmanuil Elli
Abstract excerpt
Tumor protein p53 (TP53) is the most frequently mutated gene in cancer1,2. In patients with myelodysplastic syndromes (MDS), TP53 mutations are associated with high-risk disease3,4, rapid transformation to acute myeloid leukemia (AML)5, resistance to conventional therapies6-8 and dismal outcomes9. Consistent with the tumor-suppressive role of TP53, patients harbor both mono- and biallelic mutations10. However,...
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