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Article

Novel scheme for defining the clinical implications of TP53 mutations in myeloid neoplasia.

Journal of hematology & oncology - 3 Aug 2023

Bahaj Waled, Kewan Tariq, Gurnari Carmelo, Durmaz Arda, Ponvilawan Ben, Pandit Ishani, Kubota Yasuo, Ogbue Olisaemeka D, Zawit Misam, Madanat Yazan, Bat Taha, Balasubramanian Suresh K, Awada Hussein, Ahmed Ramsha, Mori Minako, Meggendorfer Manja, Haferlach Torsten, Visconte Valeria, Maciejewski Jaroslaw P

Abstract excerpt

BACKGROUND: TP53 mutations (TP53MT) occur in diverse genomic configurations. Particularly, biallelic inactivation is associated with poor overall survival in cancer. Lesions affecting only one allele might not be directly leukemogenic, questioning the presence of cryptic biallelic subclones in cases with dismal prognosis. METHODS: We have collected clinical and molecular data of 7400 patients with myeloid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37537667
DOI: 10.1186/s13045-023-01480-y
PMCID: PMC10401750

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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