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Article

A clinical guide to TP53 mutations in myeloid neoplasms.

Blood - 30 Oct 2025

Urrutia Samuel, Wong Terrence N, Link Daniel C

Abstract excerpt

ABSTRACT: TP53 mutations are found in 10% to 15% of myeloid neoplasms and are one of its most important prognostic factors. Emerging data show that TP53 mutational allele status is a key determinant of clinical outcomes, with multihit TP53 mutant myeloid neoplasms having a very poor prognosis. Significant differences exist among the methods used in clinical and research settings to assess TP53 mutational status,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40729726
DOI: 10.1182/blood.2025029691
PMCID: PMC12983017

Genes

TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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