Article

Myeloid cell-mediated killing of B-ALL by CD38 and CD20 IgA antibody variants is enhanced by CD47/SIRPα interference

2025-08-13

Abstract excerpt

Enhancing myeloid effector cell recruitment may improve immunotherapy by monoclonal antibodies – including that against acute lymphoblastic leukemia (ALL). To assess expression of target antigens in B-ALL, we compared mRNA profiling of 559 patient leukemia samples across 18 molecular subtypes with that of representative cell lines. The latter served as target cells to compare human IgG1 or IgA2 variants against CD...

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Literature Corpus work: 12394a33-1f5e-592b-8660-59c82802df50
DOI: 10.1101/2025.08.13.669665

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Myeloid cell-mediated killing of B-ALL by CD38 and CD20 IgA antibody variants is enhanced by CD47/SIRPα interferenceDOI 10.1101/2025.08.13.669665Read

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