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The relevance of tumor target expression levels on IgA-mediated cytotoxicity in cancer immunotherapy

3 Oct 2024

Abstract excerpt

Recent advances in cancer immunotherapy, particularly the success of immune checkpoint inhibitors, have reignited interest in targeted monoclonal antibodies for immunotherapy. Antibody therapies aim to minimize on-target, off-tumor toxicity by targeting antigens overexpressed on tumor cells but not on healthy cells. Despite considerable efforts, some therapeutic antibodies have been linked to dose-limiting side...

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PMID: 39358557
DOI: 10.1007/s00262-024-03824-0

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