Article
The ZIC gene family in development and disease.
Clinical genetics - 1 Apr 2005
Grinberg I, Millen K J
Abstract excerpt
The human ZIC gene family is comprised of five members encoding zinc-finger transcription factors, which are the vertebrate homologs of the Drosophila odd-paired gene. Mutations in ZIC genes in humans have recently been implicated in a wide variety of congenital malformations, including Dandy-Walker malformation, holoprosencephaly, neural tube defects, and heterotaxy. Mutant analysis of these genes in mice has...
Topics
- Animals
- Carrier Proteins
- DNA-Binding Proteins
- Dandy-Walker Syndrome
- Functional Laterality
- Gene Deletion
- Gene Expression Regulation, Developmental
- Heart Defects, Congenital
- Holoprosencephaly
- Homeodomain Proteins
- Humans
- Mice
- Mutation
- Nerve Tissue Proteins
- Neural Tube Defects
- Nuclear Proteins
- Transcription Factors
- Zinc Fingers