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Article

The ZIC gene family encodes multi-functional proteins essential for patterning and morphogenesis.

Cellular and molecular life sciences : CMLS - 1 Oct 2013

Houtmeyers Rob, Souopgui Jacob, Tejpar Sabine, Arkell Ruth

Abstract excerpt

The zinc finger of the cerebellum gene (ZIC) discovered in Drosophila melanogaster (odd-paired) has five homologs in Xenopus, chicken, mice, and humans, and seven in zebrafish. This pattern of gene copy expansion is accompanied by a divergence in gene and protein structure, suggesting that Zic family members share some, but not all, functions. ZIC genes are implicated in neuroectodermal development and neural...

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Identifiers

PMID: 23443491
DOI: 10.1007/s00018-013-1285-5
PMCID: PMC11113920

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Zic2 and Zic3 synergistically control neurulation and segmentation of paraxial mesoderm in mouse embryo.Semantic proximity Read ↗

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Heterozygous deletion of the linked genes ZIC1 and ZIC4 is involved in Dandy-Walker malformation.Semantic proximity Read ↗

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