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Article

A Polygenic Risk Score for Predicting Racial and Genetic Susceptibility to Prurigo Nodularis.

The Journal of investigative dermatology - 1 Dec 2023

Vasavda Chirag, Wan Guihong, Szeto Mindy D, Marani Melika, Sutaria Nishadh, Rajeh Ahmad, Lu Chenyue, Lee Kevin K, Nguyen Nga T T, Adawi Waleed, Deng Junwen, Parthasarathy Varsha, Bordeaux Zachary A, Taylor Matthew T, Alphonse Martin P, Kwatra Madan M, Kang Sewon, Semenov Yevgeniy R, Gusev Alexander, Kwatra Shawn G

Abstract excerpt

Prurigo nodularis (PN) is an understudied inflammatory skin disease characterized by pruritic, hyperkeratotic nodules. Identifying the genetic factors underlying PN could help to better understand its etiology and guide the development of therapies. In this study, we developed a polygenic risk score that predicts a diagnosis of PN (OR = 1.41, P = 1.6 × 10-5) in two independent and continentally distinct...

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Identifiers

PMID: 37245863
DOI: 10.1016/j.jid.2023.04.033
PMCID: PMC11290854

Genes

PLCB4
TXNRD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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