Meningioma transcriptomic landscape demonstrates novel subtypes with regional associated biology and patient outcome

Abstract excerpt

<h4>Summary</h4> Meningiomas, the most common intracranial tumor, though mostly benign can be recurrent and fatal. WHO grading does not always identify high risk meningioma and better characterizations of their aggressive biology is needed. To approach this problem, we combined 13 bulk RNA-Seq datasets to create a dimension-reduced reference landscape of 1298 meningiomas. Clinical and genomic metadata effectively...

Topics

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• Data Analysis
• DNA Methylation
• Drug Discovery
• Glioma Diagnosis and Treatment
• Meningioma
• Meningioma and schwannoma management
• Pituitary Gland Disorders and Treatments
• Proteogenomics

Identifiers and source

Literature Corpus work

01356b40-cb65-5f94-9401-ad26ebf14097

DOI

10.1101/2024.02.23.581766