Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome.

doi:10.1200/JCO.2010.28.5148

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Article

Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Apr 2011

Cho Yoon-Jae, Tsherniak Aviad, Tamayo Pablo, Santagata Sandro, Ligon Azra, Greulich Heidi, Berhoukim Rameen, Amani Vladimir, Goumnerova Liliana, Eberhart Charles G, Lau Ching C, Olson James M, Gilbertson Richard J, Gajjar Amar, Delattre Olivier, Kool Marcel, Ligon Keith, Meyerson Matthew, Mesirov Jill P, Pomeroy Scott L

Abstract excerpt

PURPOSE: Medulloblastomas are heterogeneous tumors that collectively represent the most common malignant brain tumor in children. To understand the molecular characteristics underlying their heterogeneity and to identify whether such characteristics represent risk factors for patients with this disease, we performed an integrated genomic analysis of a large series of primary tumors. PATIENTS AND METHODS: We...

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PMID: 21098324
DOI: 10.1200/JCO.2010.28.5148
PMCID: PMC3082983

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