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Article

Decreased mechanotransduction prevents nuclear collapse in a Caenorhabditis elegans laminopathy.

Proceedings of the National Academy of Sciences of the United States of America - 8 Dec 2020

Huelgas-Morales Gabriela, Sanders Mark, Mekonnen Gemechu, Tsukamoto Tatsuya, Greenstein David

Abstract excerpt

The function of the nucleus depends on the integrity of the nuclear lamina, an intermediate filament network associated with the linker of nucleoskeleton and cytoskeleton (LINC) complex. The LINC complex spans the nuclear envelope and mediates nuclear mechanotransduction, the process by which mechanical signals and forces are transmitted across the nuclear envelope. In turn, the AAA+ ATPase torsinA is thought to...

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Identifiers

PMID: 33229589
DOI: 10.1073/pnas.2015050117
PMCID: PMC7733798

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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