Article

Decreased torsinA or LINC Complex Function Rescues a Laminopathy in <i>Caenorhabditis elegans</i>

2020-04-23

Abstract excerpt

The function of the nucleus depends on the integrity of the nuclear lamina, an intermediate filament network associated with the linker of nucleoskeleton and cytoskeleton (LINC) complex spanning the nuclear envelope. In turn, the AAA+ ATPase torsinA regulates force transmission from the cytoskeleton to the nucleus. In humans, mutations affecting nuclear envelope-associated proteins cause laminopathies, including p...

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Literature Corpus work: 1eb01d56-7873-5b44-bcaf-bf2a7cef934f
DOI: 10.1101/2020.04.22.055988

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