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Loss of RpoS results in attenuated <i>Escherichia coli</i> colonization of human intestinal organoids and a competitive disadvantage within the germ-free mouse intestine

2020-07-31

Abstract excerpt

Pluripotent stem-cell-derived human intestinal organoids (HIOs) are three-dimensional, multicellular structures that model a previously uncolonized, naïve intestinal epithelium in an in vitro system. We recently demonstrated that microinjection of the non-pathogenic Escherichia coli strain, ECOR2, into HIOs induced morphological and functional maturation of the HIO epithelium, including increased secretion of mu...

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Literature Corpus work
11eb326f-7d4f-577c-8d95-b6ae9ef47c02
DOI
10.1101/2020.07.30.230003
Open publication

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Loss of RpoS results in attenuated <i>Escherichia coli</i> colonization of human intestinal organoids and a competitive disadvantage within the germ-free mouse intestineDOI 10.1101/2020.07.30.230003
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