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Article

A small intestinal organoid model of non-invasive enteric pathogen-epithelial cell interactions.

Mucosal immunology - 1 Mar 2015

Wilson S S, Tocchi A, Holly M K, Parks W C, Smith J G

Abstract excerpt

Organoids mirror in vivo tissue organization and are powerful tools to investigate the development and cell biology of the small intestine. However, their application for the study of host-pathogen interactions has been largely unexplored. We have established a model using microinjection of organoids to mimic enteric infection, allowing for direct examination of pathogen interactions with primary epithelial cells...

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Identifiers

PMID: 25118165
DOI: 10.1038/mi.2014.72
PMCID: PMC4326599

Genes

NOD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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