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Prophage induction, but not production of phage particles, is required for lethal disease in a microbiome-replete murine model of enterohemorrhagic <i>E. coli</i> infection

2018-06-16

Abstract excerpt

Enterohemorrhagic Escherichia coli (EHEC) colonize intestinal epithelium by generating characteristic attaching and effacing (AE) lesions. They are lysogenized by prophage that encode Shiga toxin 2 (Stx2), which is responsible for severe clinical manifestations. As a lysogen, prophage genes leading to lytic growth and stx2 expression are repressed, whereas induction of the bacterial SOS response in response to D...

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Literature Corpus work
13d8d4c2-3860-58b0-bb02-e885a60b8e85
DOI
10.1101/348706
Open publication

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Prophage induction, but not production of phage particles, is required for lethal disease in a microbiome-replete murine model of enterohemorrhagic <i>E. coli</i> infectionDOI 10.1101/348706
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