Article
Human cytomegalovirus-encoded US2 differentially affects surface expression of MHC class I locus products and targets membrane-bound, but not soluble HLA-G1 for degradation.
Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2003
Barel Martine T, Ressing Maaike, Pizzato Nathalie, van Leeuwen Daphne, Le Bouteiller Philippe, Lenfant Francoise, Wiertz Emmanuel J H J
Abstract excerpt
Human CMV (HCMV) can elude CTL as well as NK cells by modulating surface expression of MHC class I molecules. This strategy would be most efficient if the virus would selectively down-regulate viral Ag-presenting alleles, while at the same time preserving other alleles to act as inhibitors of NK cell activation. We focused on the HCMV unique short (US) region encoded protein US2, which binds to newly synthesized...
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