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Article

Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation

10 Feb 2017

Abstract excerpt

The human cytomegalovirus (HCMV) US12 family consists of ten sequentially arranged genes (US12-21) with poorly characterized function. We now identify novel natural killer (NK) cell evasion functions for four members: US12, US14, US18 and US20. Using a systematic multiplexed proteomics approach to quantify ~1300 cell surface and ~7200 whole cell proteins, we demonstrate that the US12 family selectively targets...

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PMID: 28186488
DOI: 10.7554/elife.22206

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