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Article

The Human Cytomegalovirus US11 Gene Product Dislocates MHC Class I Heavy Chains from the Endoplasmic Reticulum to the Cytosol

1 Mar 1996

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Source

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Identifiers

PMID: 8625414
DOI: 10.1016/s0092-8674(00)81054-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Human Cytomegalovirus US11 Gene Product Dislocates MHC Class I Heavy Chains from the Endoplasmic Reticulum to the CytosolPMID 8625414Read ↗

The Human Cytomegalovirus US10 Gene Product Delays Trafficking of Major Histocompatibility Complex Class I MoleculesSemantic proximity Read ↗

Amino acid composition of α1/α2 domains and cytoplasmic tail of MHC class I molecules determine their susceptibility to human cytomegalovirus US11‐mediated down‐regulationSemantic proximity Read ↗

Human cytomegalovirus US3 modulates destruction of MHC class I moleculesSemantic proximity Read ↗

The pathway of US11-dependent degradation of MHC class I heavy chains involves a ubiquitin-conjugated intermediate.Semantic proximity Read ↗

Dislocation of a type I membrane protein requires interactions between membrane-spanning segments within the lipid bilayer.Semantic proximity Read ↗

Human cytomegalovirus inhibits antigen presentation by a sequential multistep process.Semantic proximity Read ↗

Multimodal HLA-I genotype regulation by human cytomegalovirus US10 and resulting surface patterning.Semantic proximity Read ↗

The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER.Semantic proximity Read ↗

Ubiquitination is essential for human cytomegalovirus US11-mediated dislocation of MHC class I molecules from the endoplasmic reticulum to the cytosol.Semantic proximity Read ↗

Binding of human cytomegalovirus US2 to major histocompatibility complex class I and II proteins is not sufficient for their degradation.Semantic proximity Read ↗

Human cytomegalovirus-encoded US2 differentially affects surface expression of MHC class I locus products and targets membrane-bound, but not soluble HLA-G1 for degradation.Semantic proximity Read ↗

The Human Cytomegalovirus Nonstructural Glycoprotein UL148 Reorganizes the Endoplasmic ReticulumSemantic proximity Read ↗

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