Article

Mutational landscape and <i>in silico</i> structure models of SARS-CoV-2 Spike Receptor Binding Domain reveal key molecular determinants for virus-host interaction

2020-05-02

Abstract excerpt

Protein-protein interactions between virus and host are crucial for infection. SARS-CoV-2, the causative agent of COVID-19 pandemic is an RNA virus prone to mutations. Formation of a stable binding interface between the Spike (S) protein R eceptor B inding D omain (RBD) of SARS-CoV-2 and A ngiotensin- C onverting E nzyme 2 (ACE2) of host actuates viral entry. Yet, how this binding interface evolves as virus...

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Literature Corpus work: 119f05f0-d10a-5b8b-8e5e-4a8110eface6
DOI: 10.1101/2020.05.02.071811

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