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Article

A 3D structural SARS-CoV-2-human interactome to explore genetic and drug perturbations.

Nature methods - 1 Dec 2021

Wierbowski Shayne D, Liang Siqi, Liu Yuan, Chen You, Gupta Shagun, Andre Nicole M, Lipkin Steven M, Whittaker Gary R, Yu Haiyuan

Abstract excerpt

Emergence of new viral agents is driven by evolution of interactions between viral proteins and host targets. For instance, increased infectivity of SARS-CoV-2 compared to SARS-CoV-1 arose in part through rapid evolution along the interface between the spike protein and its human receptor ACE2, leading to increased binding affinity. To facilitate broader exploration of how pathogen-host interactions might impact...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34845387
DOI: 10.1038/s41592-021-01318-w
PMCID: PMC8665054

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