Article

Evolutionary trajectory of receptor binding specificity and promiscuity of the spike protein of SARS-CoV-2

2022-06-11

Abstract excerpt

SARS-CoV-2 infects cells by attachment to its receptor – the angiotensin converting enzyme 2 (ACE2). Regardless of the wealth of structural data, little is known about the physicochemical mechanism of interactions of the viral spike (S) protein with ACE2 and how this mechanism has evolved during the pandemic. Here, we applied experimental and computational approaches to characterize the molecular interaction of S...

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Literature Corpus work: b256ecfb-be61-5070-aa37-409e70ce0b88
DOI: 10.1101/2022.06.11.495733

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