Article
Taxonomy of breast cancer based on normal cell phenotype predicts outcome.
The Journal of clinical investigation - 1 Feb 2014
Santagata Sandro, Thakkar Ankita, Ergonul Ayse, Wang Bin, Woo Terri, Hu Rong, Harrell J Chuck, McNamara George, Schwede Matthew, Culhane Aedin C, Kindelberger David, Rodig Scott, Richardson Andrea, Schnitt Stuart J, Tamimi Rulla M, Ince Tan A
Abstract excerpt
Accurate classification is essential for understanding the pathophysiology of a disease and can inform therapeutic choices. For hematopoietic malignancies, a classification scheme based on the phenotypic similarity between tumor cells and normal cells has been successfully used to define tumor subtypes; however, use of normal cell types as a reference by which to classify solid tumors has not been widely...
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