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Article

Genetic diversity of tumors with mismatch repair deficiency influences anti–PD-1 immunotherapy response

2 May 2019

Abstract excerpt

Tumors with mismatch repair deficiency (MMR-d) are characterized by sequence alterations in microsatellites and can accumulate thousands of mutations. This high mutational burden renders tumors immunogenic and sensitive to programmed cell death-1 (PD-1) immune checkpoint inhibitors. Yet, despite their tumor immunogenicity, patients with MMR-deficient tumors experience highly variable responses, and roughly half...

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PMID: 31048490
DOI: 10.1126/science.aau0447

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