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Immune Activation in Mismatch Repair–Deficient Carcinogenesis: More Than Just Mutational Rate

5 Aug 2019

Abstract excerpt

Mismatch repair (MMR)-deficient colorectal cancers (dMMR colorectal cancer) are characterized by the expression of highly immunogenic neoantigen peptides, which stimulate lymphocytic infiltration as well as upregulation of inflammatory cytokines. These features are key to understanding why immunotherapy (specifically PD-1 and/or CTLA-4 checkpoint blockade) has proved to be highly effective for the treatment of...

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PMID: 31383734
DOI: 10.1158/1078-0432.ccr-18-0856

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