Article

Single cell and bulk transcriptomic analyses support patient specific malignant cell state remodeling after neoadjuvant therapy in locally advanced rectal cancer

2026-08-26

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Neoadjuvant therapy can remodel malignant cells and the tumor microenvironment in locally advanced rectal cancer, but whether post-treatment changes mainly reflect clonal replacement or transcriptional state shifts within shared genomic backgrounds remains unclear. <bold>Methods</bold> GSE254249 was used as the primary single-cell cohort. Seventeen paired pa...

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Literature Corpus work: 110db0a1-7c55-59f8-81d6-750018ee7b8c
DOI: 10.21203/rs.3.rs-10598815/v1

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