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Article

Vascular NRP2 triggers PNET angiogenesis by activating the SSH1-cofilin axis

23 Sept 2020

Abstract excerpt

BACKGROUND: Angiogenesis is a critical step in the growth of pancreatic neuroendocrine tumors (PNETs) and may be a selective target for PNET therapy. However, PNETs are robustly resistant to current anti-angiogenic therapies that primarily target the VEGFR pathway. Thus, the mechanism of PNET angiogenesis urgently needs to be clarified. METHODS: Dataset analysis was used to identify angiogenesis-related genes in...

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PMID: 32983407
DOI: 10.1186/s13578-020-00472-6

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