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Article

The neuropilin 2 isoform NRP2b uniquely supports TGFβ-mediated progression in lung cancer

17 Jan 2017

Abstract excerpt

Neuropilins (NRP1 and NRP2) are co-receptors for heparin-binding growth factors and class 3 semaphorins. Different isoforms of NRP1 and NRP2 are produced by alternative splicing. We found that in non-small cell lung cancer (NSCLC) cell lines, transforming growth factor-β (TGFβ) signaling preferentially increased the abundance of NRP2b. NRP2b and NRP2a differ only in their carboxyl-terminal regions. Although the...

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PMID: 28096505
DOI: 10.1126/scisignal.aag0528

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