Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PFN2, a novel marker of unfavorable prognosis, is a potential therapeutic target involved in esophageal squamous cell carcinoma.

Journal of translational medicine - 17 May 2016

Cui Xiao-Bin, Zhang Shu-Mao, Xu Yue-Xun, Dang Hong-Wei, Liu Chun-Xia, Wang Liang-Hai, Yang Lan, Hu Jian-Ming, Liang Wei-Hua, Jiang Jin-Fang, Li Na, Li Yong, Chen Yun-Zhao, Li Feng

Abstract excerpt

BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is one of the most aggressively malignant tumors with dismal prognosis. Profilin 2 (PFN2) is an actin-binding protein that regulates the dynamics of actin polymerization and plays a key role in cell motility. Recently, PFN2 have emerged as significant regulators of cancer processes. However, the clinical significance and biological function of PFN2 in ESCC...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma in Situ
Share to Cell Shape

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial-Mesenchymal Transition

Share to Epithelium

Share to Esophageal Squamous Cell Carcinoma

Share to Precancerous Conditions

Share to Profilins

Share to ROC Curve

Source

Open in PubMed Open full text

Identifiers

PMID: 27188458
DOI: 10.1186/s12967-016-0884-y
PMCID: PMC4870769

Genes

PFN2
ZEB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PFN2, a novel marker of unfavorable prognosis, is a potential therapeutic target involved in esophageal squamous cell carcinoma.PMID 27188458Read ↗

Role of COL3A1 and POSTN on Pathologic Stages of Esophageal CancerSemantic proximity Read ↗

A three‐gene signature from protein–protein interaction network of LOXL 2‐ and actin‐related proteins for esophageal squamous cell carcinoma prognosisSemantic proximity Read ↗

Long Noncoding RNA WDFY3-AS2 Represses the Progression of Esophageal Cancer through miR-18a/PTEN AxisSemantic proximity Read ↗

UBE2C Is a Potential Biomarker of Intestinal-Type Gastric Cancer With Chromosomal InstabilitySemantic proximity Read ↗

NEK2 Promotes the Migration, Invasion, Proliferation and Drug Resistance of ESCC Through the E2F1-IGF2 PathwaySemantic proximity Read ↗

SNRPB2 facilitates esophageal squamous cell carcinoma oncogenesis and progression via E2F4 stabilizationSemantic proximity Read ↗

E2F transcription factor 1 is involved in the phenotypic modulation of esophageal squamous cell carcinoma cells via microRNA-375.Semantic proximity Read ↗

TGF-β-induced PLEK2 promotes metastasis and chemoresistance in oesophageal squamous cell carcinoma by regulating LCN2.Semantic proximity Read ↗

ADIRF expression reversely correlates with stage progression and involves keratinocyte differentiation in esophageal squamous cell carcinomaSemantic proximity Read ↗

LncRNA POU6F2-AS2 contributes to malignant phenotypes and paclitaxel resistance by promoting SKP2 expression in stomach adenocarcinoma.Semantic proximity Read ↗

Profilin 2 regulates pyruvate kinase M2 nuclear translocation and potentiates tumor angiogenesis in non-small cell lung cancerSemantic proximity Read ↗

CDKN3 promotes cell proliferation, invasion and migration by activating the AKT signaling pathway in esophageal squamous cell carcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.