Article

Expert-guided protein Language Models enable accurate and blazingly fast fitness prediction

2024-04-28

Abstract excerpt

Exhaustive experimental annotation of the effect of all known protein variants remains daunting and expensive, stressing the need for scalable effect predictions. We introduce VespaG, a blazingly fast missense amino acid variant effect predictor, leveraging protein Language Model (pLM) embeddings as input to a minimal deep learning model. To overcome the sparsity of experimental training data, we created a dataset...

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Literature Corpus work: 7d0258aa-7872-5a50-b61b-d03c67c1e32e
DOI: 10.1101/2024.04.24.590982

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