Article

Novel pedigree analysis implicates DNA repair and chromatin remodeling in Multiple Myeloma risk

2017-05-12

Abstract excerpt

<h4>ABSTRACT</h4> The high-risk pedigree (HRP) design is an established strategy to discover rare, highly-penetrant, Mendelian-like causal variants. Its success, however, in complex traits has been modest, largely due to challenges of genetic heterogeneity and complex inheritance models. We describe a HRP strategy that addresses intra-familial heterogeneity, and identifies inherited segments important for mapping...

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Literature Corpus work: 109b6120-b341-5267-9c01-f7396ccc582d
DOI: 10.1101/137000

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