Article
The Spectrum and Clinical Impact of Epigenetic Modifier Mutations in Myeloma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2016
Pawlyn Charlotte, Kaiser Martin F, Heuck Christoph, Melchor Lorenzo, Wardell Christopher P, Murison Alex, Chavan Shweta S, Johnson David C, Begum Dil B, Dahir Nasrin M, Proszek Paula Z, Cairns David A, Boyle Eileen M, Jones John R, Cook Gordon, Drayson Mark T, Owen Roger G, Gregory Walter M, Jackson Graham H, Barlogie Bart, Davies Faith E, Walker Brian A, Morgan Gareth J
Abstract excerpt
PURPOSE: Epigenetic dysregulation is known to be an important contributor to myeloma pathogenesis but, unlike other B-cell malignancies, the full spectrum of somatic mutations in epigenetic modifiers has not been reported previously. We sought to address this using the results from whole-exome sequencing in the context of a large prospective clinical trial of newly diagnosed patients and targeted sequencing in a...
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