Article

Somatic mutation phasing and haplotype extension using linked-reads in multiple myeloma

2024-08-10

Abstract excerpt

Somatic mutation phasing informs our understanding of cancer-related events, like driver mutations. We generated linked-read whole genome sequencing data for 23 samples across disease stages from 14 multiple myeloma (MM) patients and systematically assigned somatic mutations to haplotypes using linked-reads. Here, we report the reconstructed cancer haplotypes and phase blocks from several MM samples and show how p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6cdcf4af-7083-53f6-96d0-8e4d785bf4d7
DOI: 10.1101/2024.08.09.607342

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Somatic mutation phasing and haplotype extension using linked-reads in multiple myelomaDOI 10.1101/2024.08.09.607342Read

Genomic landscape and chronological reconstruction of driver events in multiple myelomaSemantic proximity Read

Genomic landscape and chronological reconstruction of driver events in multiple myelomaSemantic proximity Read

Reconstructing the evolutionary history of multiple myeloma.Semantic proximity Read

Utilizing next-generation sequencing in the management of multiple myeloma.Semantic proximity Read

Genomic landscape of multiple myeloma and its precursor conditionsSemantic proximity Read

Whole-genome sequencing reveals progressive versus stable myeloma precursor conditions as two distinct entities.Semantic proximity Read

Revealing the impact of recurrent and rare structural variants in multiple myelomaSemantic proximity Read

Whole-genome sequencing of multiple myeloma from diagnosis to plasma cell leukemia reveals genomic initiating events, evolution, and clonal tidesSemantic proximity Read

A multiple myeloma-specific capture sequencing platform discovers novel translocations and frequent, risk-associated point mutations in IGLL5.Semantic proximity Read

Longitudinal analysis of 25 sequential sample-pairs using a custom multiple myeloma mutation sequencing panel (M(3)P).Semantic proximity Read

Linked-read whole-genome sequencing resolves common and private structural variants in multiple myelomaSemantic proximity Read

Mutational processes contributing to the development of multiple myelomaSemantic proximity Read