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Article

Haplotype analysis identifies functional elements in monoclonal gammopathy of unknown significance.

Blood cancer journal - 20 Aug 2024

Thomsen Hauke, Chattopadhyay Subhayan, Weinhold Niels, Vodicka Pavel, Vodickova Ludmila, Hoffmann Per, Nöthen Markus M, Jöckel Karl-Heinz, Schmidt Börge, Hajek Roman, Hallmans Göran, Pettersson-Kymmer Ulrika, Späth Florentin, Goldschmidt Hartmut, Hemminki Kari, Försti Asta

Abstract excerpt

Genome-wide association studies (GWASs) based on common single nucleotide polymorphisms (SNPs) have identified several loci associated with the risk of monoclonal gammopathy of unknown significance (MGUS), a precursor condition for multiple myeloma (MM). We hypothesized that analyzing haplotypes might be more useful than analyzing individual SNPs, as it could identify functional chromosomal units that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39164264
DOI: 10.1038/s41408-024-01121-8
PMCID: PMC11335940

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