Article

Computationally accelerated identification of P-glycoprotein inhibitors

2024-03-07

Abstract excerpt

Overexpression of the polyspecific efflux transporter, P-glycoprotein (P-gp, MDR1, ABCB1 ), is a major mechanism by which cancer cells acquire multidrug resistance (MDR), the resistance to diverse chemotherapeutic drugs. Inhibiting drug transport by P-gp can resensitize cancer cells to chemotherapy, but there are no P-gp inhibitors available to patients. Clinically unsuccessful P-gp inhibitors tend to bind at the...

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Literature Corpus work: 107b80c9-dd0e-5c66-9d80-0563850acdef
DOI: 10.1101/2024.03.05.583428

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