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A Quantitative Approach for Assessing Multidrug Resistance in Cancer

2024-11-03

Abstract excerpt

Multidrug resistance (MDR) is a primary barrier to successful cancer treatment with small molecule drugs. One mechanism of resistance is through transporters which pump drug out of cancer cells before they exert any therapeutic effect. The most studied transporter is P-glycoprotein (Pgp), a member of the ATP Binding Cassette (ABC) superfamily of drug pumps. Prior research has focused on determining whether drugs a...

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Literature Corpus work
9ab0d891-5fc4-573a-96c7-0921af3616c1
DOI
10.1101/2024.11.02.621654
Open publication

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A Quantitative Approach for Assessing Multidrug Resistance in CancerDOI 10.1101/2024.11.02.621654
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