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Article

Screening of Natural Compounds as P-Glycoprotein Inhibitors against Multidrug Resistance

30 Mar 2021

Abstract excerpt

Multidrug resistance (MDR) is a common problem when fighting cancer with chemotherapy. P-glycoprotein (P-gp, or MDR1) is an active pump responsible for the efflux of xenobiotics out of the cell, including anti-cancer drugs. It is a validated target against MDR. No crystal structure of the human P-gp is available to date, and only recently several cryo-EM structures have been solved. In this paper, we present a...

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PMID: 33808505
DOI: 10.3390/biomedicines9040357

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