Article

Vitamin D Sufficiency Enhances Differentiation of Patient-Derived Prostate Epithelial Organoids

2020-07-17

Abstract excerpt

<h4>SUMMARY</h4> Vitamin D is an essential steroid hormone that regulates systemic calcium homeostasis and cell fate decisions, including differentiation in many cell types. The prostate gland is hormonally regulated, requiring steroids for proliferation and terminal differentiation of secretory luminal cells. Vitamin D deficiency is associated with higher risk of lethal prostate cancer with an aggressive dediffe...

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Literature Corpus work: 10587f67-5b58-5d47-b2f4-c1b97121b40b
DOI: 10.1101/2020.07.17.208694

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