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Isolation and functional interrogation of adult human prostate epithelial stem cells at single cell resolution

17 Jun 2017

Abstract excerpt

Using primary cultures of normal human prostate epithelial cells, we developed a novel prostasphere-based, label-retention assay that permits identification and isolation of stem cells at a single cell level. Their bona fide stem cell nature was corroborated using in vitro and in vivo regenerative assays and documentation of symmetric/asymmetric division. Robust WNT10B and KRT13 levels without E-cadherin or KRT14...

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PMID: 28651114
DOI: 10.1016/j.scr.2017.06.009

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